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Targeting xCT, a cystine-glutamate transporter induces apoptosis and tumor regression for KSHV/HIV-associated lymphoma

Lu Dai, Yueyu Cao, Yihan Chen, Chris Parsons and Zhiqiang Qin*

  • * Corresponding author: Zhiqiang Qin

  • † Equal contributors

Journal of Hematology & Oncology 2014, 7:30  doi:10.1186/1756-8722-7-30

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Negative-feedback loop between Nrf2/KEAP1 axis and xCT-GSH axis in PEL cells

Go Yoshida   (2014-07-25 14:42)  Tokyo Medical and Dental University email

The authors investigated the role of xCT transporter in primary effusion lymphoma (PEL). The treatment of KSHV-infected PEL cells with monosodium glutamate (MSG) and sulfasalazine (SASP) disrupted the synthesis of glutathione (GSH), thereby activating Rac1/p22phox/Nox1/Nox2 axis. Ishii T et al. have recently reviewed that Nrf2 signal pathway contributes to the expression of xCT (Redox Biol. 2014 Apr 18;2:786-794). Thus, it is likely that negative-feedback loop between Nrf2/KEAP1 axis and xCT-GSH axis might exist, resulting in keeping the ROS level in the intermediated level preferential for cellular survival and proliferation but inducing neither cell-cycle arrest nor apoptosis.

Competing interests

No Competing Interests Exist.


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