|Cellular components isolated from IH|
|Cell type||Abbreviation||Cell marker||Characteristics|
|Hemangioma-derived endothelial cell||HemEC||CD31/PECAM-1, vWF, E-selectin, VEGFR-2, Tie-2 and VE-cadherin||Immature endothelial cells; Clonal expansion; Increased proliferation, migration, tumor formation and survival ability.|
|Hemangioma-derived endothelial progenitor cell||HemPEC||CD133*, VEGFR-2, CD34, CD31, CD146, VE-cadherin and vWF||Immature endothelial cells; Increased adhesion, migration and proliferation in the presence of endostatin or VEGF.|
|Hemangioma-derived mesenchymal stem cell||Hem-MSC||SH2(CD105), SH3, SH4, CD90, CD29, α-SMA and CD133||Multilineage differentiation: adipogenic, osteoblastic and myoblastic differentiation|
|Hemangioma-derived stem cell||HemSC||CD90, CD133, VEGFR-1, VEGFR-2, neuroplin-1 and CD146||Multilineage differentiation: ECs, neuronal cells, adipocytes, osteocytes and chondrocytes; Form hemangioma-like Glut-1+ blood vessels in nude mice.|
|Hemangioma-derived pericyte||Hem-pericyte||PDGFR-β, neural glial antigen-2, desmin, calponin, smooth muscle 22α, smooth muscle α-actin, α-SMA, smooth muscle myosin heavy chain and CD90||Increased proliferation ability; Reduced contractility; Diminished ability to stabilize blood vessels in IH.|
*CD133, a pentaspan membrane protein, is used as a stem cell biomarker for the isolation of progenitor/stem-like cells from IH tissues. CD133 is also responsible for self-renewal, tumorigenesis, metabolism, differentiation, autophagy, apoptosis and regeneration . However, little is known about its biological functions in the development of IH.
Ji et al.
Ji et al. Journal of Hematology & Oncology 2014 7:13 doi:10.1186/1756-8722-7-13