Table 1

Cellular components isolated from IH
Cell type Abbreviation Cell marker Characteristics
Hemangioma-derived endothelial cell HemEC CD31/PECAM-1, vWF, E-selectin, VEGFR-2, Tie-2 and VE-cadherin Immature endothelial cells; Clonal expansion; Increased proliferation, migration, tumor formation and survival ability.
Hemangioma-derived endothelial progenitor cell HemPEC CD133*, VEGFR-2, CD34, CD31, CD146, VE-cadherin and vWF Immature endothelial cells; Increased adhesion, migration and proliferation in the presence of endostatin or VEGF.
Hemangioma-derived mesenchymal stem cell Hem-MSC SH2(CD105), SH3, SH4, CD90, CD29, α-SMA and CD133 Multilineage differentiation: adipogenic, osteoblastic and myoblastic differentiation
Hemangioma-derived stem cell HemSC CD90, CD133, VEGFR-1, VEGFR-2, neuroplin-1 and CD146 Multilineage differentiation: ECs, neuronal cells, adipocytes, osteocytes and chondrocytes; Form hemangioma-like Glut-1+ blood vessels in nude mice.
Hemangioma-derived pericyte Hem-pericyte PDGFR-β, neural glial antigen-2, desmin, calponin, smooth muscle 22α, smooth muscle α-actin, α-SMA, smooth muscle myosin heavy chain and CD90 Increased proliferation ability; Reduced contractility; Diminished ability to stabilize blood vessels in IH.

*CD133, a pentaspan membrane protein, is used as a stem cell biomarker for the isolation of progenitor/stem-like cells from IH tissues. CD133 is also responsible for self-renewal, tumorigenesis, metabolism, differentiation, autophagy, apoptosis and regeneration [23]. However, little is known about its biological functions in the development of IH.

Ji et al.

Ji et al. Journal of Hematology & Oncology 2014 7:13   doi:10.1186/1756-8722-7-13

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