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Open Access Review

Different mutations of the human c-mpl gene indicate distinct haematopoietic diseases

Xin He1, Zhigang Chen2, Yangyan Jiang3, Xi Qiu1 and Xiaoying Zhao1*

Author Affiliations

1 Department of Hematology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China

2 Department of Oncology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China

3 UItrasonic Diagnosis Deparment, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China

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Journal of Hematology & Oncology 2013, 6:11  doi:10.1186/1756-8722-6-11

Published: 25 January 2013

Abstract

The human c-mpl gene (MPL) plays an important role in the development of megakaryocytes and platelets as well as the self-renewal of haematopoietic stem cells. However, numerous MPL mutations have been identified in haematopoietic diseases. These mutations alter the normal regulatory mechanisms and lead to autonomous activation or signalling deficiencies. In this review, we summarise 59 different MPL mutations and classify these mutations into four different groups according to the associated diseases and mutation rates. Using this classification, we clearly distinguish four diverse types of MPL mutations and obtain a deep understand of their clinical significance. This will prove to be useful for both disease diagnosis and the design of individual therapy regimens based on the type of MPL mutations.

Keywords:
MPL; Mutations; Mechanism; Individual therapy; Haematopoietic diseases