Table 1

Reasons to Suspect AL Amyloidosis

1.

Non-diabetic nephrotic syndrome

2.

Non-ischemic cardiomyopathy and hypertrophy*

3.

Hepatomegaly or increased alkaline phosphatase**

4.

Monoclonal gammopathy with

a. Autonomic or sensory neuropathy

b. Unexplained fatigue

c. Edema

d. Unintentional weight loss

Signs and symptoms that may represent AL amyloidosis in a patient. Non-diabetic nephrotic syndrome; non-ischemic cardiomyopathy and hypertrophy on echocardiogram, especially in the absence of hypertension*; hepatomegaly or increased alkaline phosphatase with no liver abnormalities by imaging**; or autonomic neuropathy with orthostasis or sensory neuropathy with a monoclonal protein. In patients with monoclonal gammopathy and unexplained fatigue, edema, weight loss or paresthesias, AL amyloidosis should also be considered.

Rosenzweig and Landau Journal of Hematology & Oncology 2011 4:47   doi:10.1186/1756-8722-4-47