Table 1

Classification of mast cell activation disease (modified from [2-4]).

Mast cell activation disease (MCAD)

Mast cell activation syndrome (MCAS)

Systemic mastocytosis (SM) defined by the WHO criteria

• Indolent systemic mastocytosis

• Isolated bone marrow mastocytosis

• Smoldering systemic mastocytosis

• Systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease

• Aggressive systemic mastocytosis

Mast cell leukemia (MCL)

Molderings et al. Journal of Hematology & Oncology 2011 4:10   doi:10.1186/1756-8722-4-10