www.jhoonline.org

Table 1
Cutaneous manifestations of internal malignancies
Cutaneous feature	Clinical findings	Associated malignancy

Acanthosis nigricans (malignant)	Velvety hyperpigmented thickening extending beyond the flexures and neck to involve lips, palms	Intra-abdominal adenocarcinoma, lung carcinoma, lymphoreticular malignancies

Acrokeratosis paraneoplastica (Bazex's syndrome)	Psoriasiform dermatitis with nail dystrophy affecting hands, feet, ears, nose	Squamous cell carcinoma of upper aerodigestive tract

Erythema gyratum repens	Wood grain pattern annular, scaling erythema	Lung carcinoma

Necrolytic migratory erythema	Eroded erythematous annular polycyclic eruption affecting intertriginous areas	Glucagonoma

Sweet syndrome	Plum coloured nodules affecting head, neck and dorsae, hands	Can be associated with leukaemia, lymphoma, multiple myeloma

Pyoderma gangrenosum especially bullous variant	Painful inflammatory ulcers with raised violaceous edge and overhanging borders; associated pathergy	Can be associated with leukaemia, lymphoma, multiple myeloma

Paraneoplastic pemphigus	Bullous, erosive mucosal +/- cutaneous eruption	Haematologic malignancies, thymoma

Necrobiotic xanthogranuloma	Purpuric yellow plaques in periorbital and flexural areas	Monoclonal gammopathy/multiple myeloma

Diffuse plane xanthomas	Yellow-orange macules and plaques	Monoclonal gammopathy/multiple myeloma

Scleromyxoedema	Scleroderma-like thickening of skin associated with coloured skin or erythematous papular infiltrate	Monoclonal gammopathy/multiple myeloma

Primary systemic amyloidosis	Macroglossia, purpura especially periorbital and infiltrated papules	Monoclonal gammopathy/multiple myeloma

Ponti et al. Journal of Hematology & Oncology 2010 3:2 doi:10.1186/1756-8722-3-2

Table 1