Table 3 |
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|
Response and PFS by RRM1 SNPs |
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|
RRM1 SNPs |
Response1 (n) |
P value2 |
PFS(weeks) |
P value3 |
||
|
|
||||||
|
PR |
SD |
PD |
||||
|
|
||||||
|
A(-)37A |
1 |
7 |
2 |
24.7 |
||
|
C(-)37C |
2 |
20 |
2 |
23.3 |
||
|
A(-)37C |
6 |
14 |
2 |
0.514 |
30.7 |
0.043 |
|
A2455A |
5 |
22 |
2 |
26.9 |
||
|
G2455G |
2 |
6 |
3 |
22.0 |
||
|
A2455G |
2 |
13 |
1 |
0.849 |
30.7 |
0.327 |
|
G2464G |
0 |
7 |
1 |
23.9 |
||
|
A2464A |
6 |
20 |
5 |
24.7 |
||
|
G2464A |
3 |
13 |
1 |
0.191 |
27.4 |
0.973 |
|
|
||||||
|
1 Genomic DNA from 56 patients was available for the analysis of RRM1 SNPs and response. 2 Kendall's tau correlation 3 Kaplan-Meier survival estimates. Abbreviations: PR, Partial response; SD, Stable disease; PD, Progressive disease; PFS, Progression-free survival. |
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|
Dong et al. Journal of Hematology & Oncology 2010 3:10 doi:10.1186/1756-8722-3-10 |
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