Table 2

Association of iron parameters on transplant survival

Iron Parameter(s)

Median

Relative Risk

p-value

Included in iron score


Blood Transfusions (units)

22

1.40

0.007

YES

Serum Ferritin (ng/mL)

1103

1.36

0.02

YES

Marrow Iron Stain Grade10

4+

1.34

0.08

YES

Transferrin

193

0.77

0.11

No

Transferrin Receptor

6.1

0.80

0.12

No

Serum Iron (mcg/dL)

90

0.91

0.50

No

Transferrin Saturation (%)

30

1.08

0.54

No

Ferritin + Transfusions*

--

1.43

0.002

--

Ferritin + Iron Stain*

--

1.49

0.010

--

Transfusion + Iron Stain*

--

1.58

0.003

--

Transplant Iron Score*

--

1.77

0.0006

--


The relative risk represents the relative risk of death associated with each incremental increase in quartile (e.g. 50th to 75th quartile) among the iron parameters. The following cutoff values were used to assign patients to the various groupings: (1) serum ferritin ≥ 1,000 ng/mL, (2) greater than 25 transfused units of red cells, and (3) bone marrow iron stain of 6+. The Transplant Iron Score is calculated by assigning patients one point for each of the values above the cutoff.

*The calculated relative risks were scaled (i.e. scored on a 0-3 scale) to allow comparisons to the individual iron quartiles.

Storey et al. Journal of Hematology & Oncology 2009 2:44   doi:10.1186/1756-8722-2-44

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