Case report

Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

Michihide Tokuhira¹ , Kyoko Hanzawa¹ , Reiko Watanabe¹ , Yasunobu Sekiguchi¹ , Tomoe Nemoto¹ , Yasuo Toyozumi² , Jun-ichi Tamaru² , Shinji Itoyama² , Katsuya Suzuki³ , Hideto Kameda³ , Shigehisa Mori¹ and Masahiro Kizaki¹

¹  Division of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan

²  Division of Pathology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan

³  Department of Rheumatology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan

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Journal of Hematology & Oncology 2009, 2:27doi:10.1186/1756-8722-2-27

Published:	30 June 2009

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease mediated by inflammatory processes mainly at the joints. Recently, awareness of Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder (T-LPD) has been heightened for its association with methotraxate usage in RA patients. In the contrary, acute myeloid leukemia with multilineage dysplasia (AML-MLD) has never been documented to be present concomitantly with the above two conditions. In this report we present a case of an autopsy-proven co-existence of AML-MLD and EBV-associated T-LPD in a patient with RA.