Case report
Treatment of multicentric Castleman's Disease accompanying multiple myeloma with bortezomib: a case report
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* Corresponding author: Jian Hou houjian167@sohu.com
Department of Hematology, Second Affiliated Hospital to the Second Military Medical University, 415 Fengyang Rd, Shanghai 200003, PR China
Journal of Hematology & Oncology 2009, 2:19 doi:10.1186/1756-8722-2-19
Published: 28 April 2009Abstract
Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder of unknown etiology and characterized by various clinical manifestations and multiple organ involvement. It has been reported in association with POEMS syndrome and can progress to Kaposi's sarcoma or malignant lymphoma. The disease runs a more aggressive course and a poor prognosis. Optimal therapies have not been well established up to now. We here reported a case of rare MCD complicated with multiple myeloma who received bortezomib and achieved very good remission. To our knowledge, this is the first report on MCD in the setting of multiple myeloma with good response to bortezomib.