Figure 2.

H&E staining and immunohistochemical characteristics of tumor cells. A. CT guided biopsy of the mediastinal mass (H&E staining) showing diffuse proliferation of medium sized lymphoid cells, exhibiting fine nuclear chromatin, inconspicuous nucleoli and scanty cytoplasm. Occasional mitosis with few scattered tangible body macrophages was noted. An area of necrosis was also noticed within the tumor. B. CD1a positive neoplastic cells from mediastinal biopsy aspirate. C. Synaptophysin positive neoplastic cells from mediastinal biopsy aspirate. D. CD3 positive neoplastic cells from mediastinal biopsy aspirate. E. H&E staining of the CT guided liver biopsy revealing the same tumor cell morphology as that of CT guided mediastinal mass biopsy. It also revealed intrahepatic cholestasis in the form of intracanalicular bile plugs. F. H&E staining of the bone marrow biopsy showing the same tumor cell morphology as that of CT guided mediastinal mass biopsy.